[{"data":1,"prerenderedAt":315},["ShallowReactive",2],{"\u002Fresearchers\u002Farticles-resources":3},{"id":4,"title":5,"body":6,"description":304,"extension":307,"meta":308,"navigation":309,"path":310,"printable":309,"seo":311,"spanish":312,"stem":313,"__hash__":314},"page\u002Fresearchers\u002Farticles-resources.md","Articles and Resources",{"type":7,"value":8,"toc":303},"minimark",[9],[10,11,12,20,26,27,26,30,101,26,105,26,107,237,26,241,26,243],"layout-content",{},[13,14],"heading",{"className":15,"level":19,"text":5},[16,17,18],"rvt-ts-lg","rvt-text-uppercase","rvt-m-bottom-lg","1",[13,21],{"className":22,"level":24,"text":25},[23],"rvt-ts-md","2","General PD Overview","  ",[28,29],"hr",{},[31,32,33,34,33,64,33,82,100],"ul",{},"\n    ",[35,36,37],"li",{},[38,39,40,41,55,61,33],"div",{},"\n        ",[42,43,46,47],"a",{"href":44,"target":45},"https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fbooks\u002FNBK1223\u002F","_blank","Monogenic Parkinson Disease Overview",[48,49],"img",{"src":50,"style":51,"className":52,"alt":54},"\u002Fassets\u002Fimg\u002Ficons\u002Fdocument.svg","max-width:15px",[53],"svg-icon","PDF Resource",[56,57,60],"p",{"className":58},[59],"citation","Morris H, Lim SY. Monogenic Parkinson Disease Overview. 2004 May 25 [Updated 2025 May 15]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025.",[56,62,63],{},"Informative review of the genetics of Parkinson’s disease including an evaluation strategy to identify the genetic cause of Parkinson’s disease in a patient and information for family members including genetic counseling.",[35,65,66],{},[38,67,40,68,75,79,33],{},[42,69,71,72],{"href":70,"target":45},"https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F25904081\u002F","Parkinson’s Disease",[48,73],{"src":50,"style":51,"className":74,"alt":54},[53],[56,76,78],{"className":77},[59],"Bloem, B. R., Okun, M. S. & Klein, C. Parkinson’s disease. Lancet 397, 2284–2303 (2021)",[56,80,81],{},"A review of the complexities and challenges of PD including clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis, and treatment.",[35,83,84],{},[38,85,40,86,93,97,33],{},[42,87,89,90],{"href":88,"target":45},"https:\u002F\u002Fghr.nlm.nih.gov\u002Fcondition\u002Fparkinson-disease#inheritanceNCP","MedlinePlus Genetic Conditions: Parkinson's Disease",[48,91],{"src":50,"style":51,"className":92,"alt":54},[53],[56,94,96],{"className":95},[59],"MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US). Parkinson's disease; [updated 2012 May 1]",[56,98,99],{},"Overview of the clinical characteristics of PD along with the frequency, causes, and inheritance of PD.","\n  ",[13,102],{"className":103,"level":24,"text":104},[23],"PD Genetics",[28,106],{},[31,108,33,109,33,155,33,173,33,191,33,207,33,221,100],{},[35,110,111],{},[38,112,40,113,120,124,33],{},[42,114,116,117],{"href":115,"target":45},"https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F28511254\u002F","Genetic Forms of Parkinson’s Disease",[48,118],{"src":50,"style":51,"className":119,"alt":54},[53],[56,121,123],{"className":122},[59],"Kim C and Alcalay R. Genetic Forms of Parkinson’s Disease. Seminars in Neurology 2017; 37:135-146  DOI: 10.1055\u002Fs-0037-1601567",[56,125,126,127,133,134,133,138,133,142,133,146,133,150,154],{},"A review of the key clinical features of the monogenic forms of PD including ",[128,129,132],"span",{"className":130},[131],"gene-text","LRRK2",", ",[128,135,137],{"className":136},[131],"GBA1",[128,139,141],{"className":140},[131],"SNCA",[128,143,145],{"className":144},[131],"VPS35",[128,147,149],{"className":148},[131],"PRKN",[128,151,153],{"className":152},[131],"PINK1",", and DJ1. Information on phenotype, clinical course, and treatment response is included.",[35,156,157],{},[38,158,40,159,166,170,33],{},[42,160,162,163],{"href":161,"target":45},"https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41531-022-00432-6","Tools for Risk Communication",[48,164],{"src":50,"style":51,"className":165,"alt":54},[53],[56,167,169],{"className":168},[59],"Cook, L., Schulze, J., Uhlmann, W.R. et al. Tools for communicating risk for Parkinson’s disease. npj Parkinsons Dis. 8, 164 (2022). https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41531-022-00432-6",[56,171,172],{},"Information on PD genes, variants, inheritance patterns, and chances of disease to be used for risk counseling.",[35,174,175],{},[38,176,40,177,184,188,33],{},[42,178,180,181],{"href":179,"target":45},"https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F31521533\u002F","The Genetic Architecture of Parkinson’s Disease",[48,182],{"src":50,"style":51,"className":183,"alt":54},[53],[56,185,187],{"className":186},[59],"Blauwendraat C, Nalls MA, and Singleton AB. The Lancet Neurology, 2020; 19(2), 170–178 DOI: 10.1016\u002FS1474-4422(19)30287-X",[56,189,190],{},"The current knowledge of PD genetics, along with the most recent developments, are reviewed.",[35,192,193],{},[38,194,40,195,204,33],{},[42,196,198,199],{"href":197,"target":45},"https:\u002F\u002Fclinicalgenome.org\u002Faffiliation\u002F40079\u002F","Clinical Genome Resource (ClinGen)",[48,200],{"src":201,"style":51,"className":202,"alt":203},"\u002Fassets\u002Fimg\u002Ficons\u002Fsearch.svg",[53],"Searchable Resource",[56,205,206],{},"View the PD gene-disease validity classifications approved by the ClinGen Parkinson’s Disease working group and gene curation panel.",[35,208,209],{},[38,210,40,211,218,33],{},[42,212,214,215],{"href":213,"target":45},"https:\u002F\u002Fwww.movementdisorders.org\u002FMDS\u002FResources\u002FMDSGene.htm","Movement Disorder Society Genetic Database (MDSGene)",[48,216],{"src":201,"style":51,"className":217,"alt":203},[53],[56,219,220],{},"Comprehensive overview of clinical data from patients with PD reported to carry causative variants",[35,222,223],{},[38,224,40,225,234,33],{},[42,226,228,229],{"href":227,"target":45},"https:\u002F\u002Fwww.michaeljfox.org\u002Fwebinar\u002Fwhats-your-dna-understanding-parkinsons-genetics","Podcast: What’s in your DNA? Understanding Parkinson’s Genetics",[48,230],{"src":231,"style":51,"className":232,"alt":233},"\u002Fassets\u002Fimg\u002Ficons\u002Fpodcast.svg",[53],"Podcast Resource",[56,235,236],{},"Podcast hosted by the Michael J Fox Foundation outlining genetic influences on Parkinson’s disease",[13,238],{"className":239,"level":24,"text":240},[23],"Genetic Testing for PD",[28,242],{},[31,244,33,245,33,267,33,285,100],{},[35,246,247],{},[38,248,40,249,256,260,263,33],{},[42,250,252,253],{"href":251,"target":45},"https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F33686495\u002F","The Role of Genetic Testing for Parkinson’s Disease",[48,254],{"src":50,"style":51,"className":255,"alt":54},[53],[56,257,259],{"className":258},[59],"Cook L, Schulze J, Naito A, Alcalay RN. Current Neurology and Neuroscience Reports, 2021, 8;21(4)17. DOI: 10.1007\u002Fs11910-021-01100-7 . (also provides downloadable patient flier about genetic testing)",[56,261,262],{},"Provides guidance on facilitating PD genetic testing in a clinical practice given the changing scene of genetic testing for PD. Also highlights the current practices and attitudes among neurologists regarding genetic testing for PD.",[56,264,266],{"className":265},[59],"*Provides downloadable patient flier about genetic testing",[35,268,269],{},[38,270,40,271,278,282,33],{},[42,272,274,275],{"href":273,"target":45},"https:\u002F\u002Fcp.neurology.org\u002Fcontent\u002F11\u002F1\u002F69","Genetic Testing for Parkinson Disease: Are We Ready?",[48,276],{"src":50,"style":51,"className":277,"alt":54},[53],[56,279,281],{"className":280},[59],"Cook L, Schulze J, et al. Genetic Testing for Parkinson Disease: Are We Ready? Neurology: Clinical Pratice March 2020   DOI: 10.1212\u002FCPJ.0000000000000831",[56,283,284],{},"A review on the current genetic landscape of PD. Describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.",[35,286,287],{},[38,288,40,289,296,300,33],{},[42,290,292,293],{"href":291,"target":45},"https:\u002F\u002Fneurology.libsyn.com\u002Fwebsite\u002F2021\u002F03","Podcast: Are we ready for gene testing in Parkinson’s?",[48,294],{"src":231,"style":51,"className":295,"alt":233},[53],[56,297,299],{"className":298},[59],"Dr. Roy Alcalay and Lola Cook Neurology® Journals Podcast, March 15, 2021",[56,301,302],{},"Dr. Jeffrey Ratliff talks with genetic counselor, Lola Cook, and neurologist, Dr. Roy Alcalay, about genetic testing for PD.",{"title":304,"searchDepth":305,"depth":305,"links":306},"",2,[],"md",{},true,"\u002Fresearchers\u002Farticles-resources",{"title":5,"description":304},false,"researchers\u002Farticles-resources","PvIP7kgnZnKA8uIUlIMeY7eDHi39tX1kwbbgh7aYW74",1776707457116]